The MODEL-AD consortium consisting of a Center at Indiana University, The Jackson Laboratory, and Sage Bionetworks and a Center at the University of California Irvine has been established by the National Institute on Aging to:

  • Develop the next generation of in vivo AD models based on human data
  • Institute a standardized and rigorous process for characterization of animal models
  • Align the pathophysiological features of AD models with corresponding stages of clinical disease using translatable biomarkers
  • Establish guidelines for rigorous preclinical testing in animal models
  • Ensure rapid availability of animal models, protocols and validation data to all researchers for preclinical drug development

MODEL-AD figure