Assessing Healthspan and Lifespan Measures in Aging Mice: Optimization of Testing Protocols, Replicability, and Rater Reliability.

The July 25 Nature has an Outlook story featuring the MODEL-AD program:

The search for better animal models of Alzheimer’s disease.

Sunday July 22
Poster P1-130  Familial Models_OBLAK_AAIC 2018 -min
MODEL-AD: Characterization of Familial AD Models (5xFAD, APP/PS1, hTau, 3xTg-AD)

Poster P1-131  MODEL AD overview-min (1)
MODEL-AD: Late-Onset Alzheimer’s Disease Models

Haβ-KI: A Knock-in Mouse Model for Sporadic Alzheimer’s Disease
O1-01-04
Room – 184
8:45am – 9:00am

Monday July 23
S2-02-01
8:00-8:20AM
Room 183
New In Vivo Models for Alzheimer’s Disease – MODEL-AD

Poster P2-045
The MODEL-AD Consortium Preclinical Testing Pipeline: Pharmacokinetics and Pharmacodynamics of Prophylactic Treatment with Leviteracetam in the 5XFAD Mouse Model of Alzheimer’s Disease

Tuesday July 24
03-03-02
8:15-8:30AM
Room 184
Systems Biology Ranking of Candidate Alzheimer’s Driver Genes Identifies New Genetic Drivers of Alzheimer’s

Wednesday July 25
O4-01-06
9:15-9:30
Room 185
Whole-Exome Analysis of Late-Onset Alzheimer’s Disease Reveals Novel Candidate Genes Involved in Cognitive Function

Poster P4-028  APOE4 trem2 model (1)_sjsr edits(2) GRH v2-min
Characterizing the APOE4/Trem2*R47H Mouse Model for Late Onset Alzheimer’s Disease

Poster P4-031  AAIC GWAS models poster PDF-min
Novel Models of Late-Onset Alzheimer’s Disease Based on GWAS

Poster P4-045
Biological Pathways and Related Protein Biomarkers of Clinical Progression in Early Alzheimer’s Disease

Monday June 11

SHORT TALKS I

15:51-16:03

GWAS-based mouse models exhibit distinct transcriptomic signatures of late-onset Alzheimer’s disease

Greg Carter (The Jackson Laboratory, USA)

 

Tuesday June 12

SESSION 6: INNATE IMMUNITY AND NEURODEGENERATION

13:10-13:35

Unraveling the Role of Innate Immune Pathways in Neurodegeneration

Bruce Lamb (Indiana University, USA)

 

Tuesday June 12

Poster P2-K14

Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease: MODEL-AD

Harriet Williams (The Jackson Laboratory, USA)

The IU/JAX MODEL-AD Center and the Indiana Alzheimer’s Disease Center hosted a scientific symposium focusing on translational approaches to Alzheimer’s disease featuring speakers from the Stark Neurosciences Institute, The Jackson Lab, Sage Bionetworks and Eli Lilly as well as a poster session.

Thanks to sponsors: Alzheimer Association; Stark Neurosciences Research Institute; IU Alzheimer’s Disease Center; and Indiana Clinical and Translational Sciences Institute.

 

A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer’s Disease.

The Jackson Laboratory will present the 3rd annual Workshop on using mouse models to study human neurodegenerative disease in May.  This course will focus on the use of the innovative tools and methods, specifically in the laboratory mouse, for answering questions of neuron and circuit function and disease mechanisms during neurodegeneration.  The course will employ both didactic and hands-on instruction in both laboratory techniques and bioinformatics.

Workshop details

The Model Organism Development and Evaluation for Late-onset-Alzheimer’s Disease (MODEL-AD) project seeks a Center Manager for the Jackson Lab site in Bar Harbor, Maine.  MODEL-AD aims to create the next generation of mouse models for AD and develop new therapeutic targets. The Center Manager is an integral team member in this multi-project, multi-institutional grant.  The successful candidate will devote effort to managing the laboratory staff, overseeing mouse colony management, data production and analyses, and presenting research updates at internal and external meetings.  Administrative responsibilities include serving as liaison between investigators at JAX, Indiana University (IU), and University of California-Irvine (UCI), communications between JAX MODEL-AD project leaders, and managing documentation for data use and lab and animal protocols. The successful candidate will be able to apply for grants to develop their own research interests that leverage the resources being developed within MODEL-AD.

 

More information and how to apply.

Some of the recent NIA Approved Concepts for funding (see https://www.nia.nih.gov/approved-concepts#collaborative ) encourage the use of mouse models created by the MODEL-AD program.  All of the models generated will be listed on the “Resources” section of this website, and will be available from JAX.  Please contact us at ModelAD@iupui.edu if you would like us to provide a letter of support.

MONDAY, NOV. 13, 2017

Session 386 Alzheimer’s Disease: Genetics and Functional Genomic (1:00 – 5:00 PM)

 

Presentation 386.01 / V26 / 1:00-2:00

Model-ad: Genetic models of late-onset Alzheimer’s disease

 

Presentation 386.05 / W4 / 1:00-2:00

MODEL-AD: The disease modeling project

 

Presentation 386.02 / W1 / 2:00-3:00

Preclinical drug screening in new generation Alzheimer’s disease mouse models: The MODEL-AD Consortium Strategy

 

Presentation 386.03 / W2 / 3:00-4:00

Novel candidate loci for Alzheimer’s disease from whole-genome and whole-exome sequencing

 

Presentation 386.04 / W3 / 4:00-5:00

Model-ad: Bioinformatics and data management core