The BDMC integrates data from multiple genetic and genomic resources to prioritize candidate genes for CRISPR editing in the mouse. Once created, phenotype data from these models are analyzed to characterize each new model. Drawing on human genomics and imaging resources, these results are matched to pathology found in humans with late-onset Alzheimer’s to determine the disease-related dysfunction caused by the genetic modifications. These genetic risk factors can then be systematically combined to create mice with a full range of Alzheimer’s pathology for preclinical testing and studies of disease biology.

BDMC Flow Chart