Monday June 11
SHORT TALKS I
GWAS-based mouse models exhibit distinct transcriptomic signatures of late-onset Alzheimer’s disease
Greg Carter (The Jackson Laboratory, USA)
Tuesday June 12
SESSION 6: INNATE IMMUNITY AND NEURODEGENERATION
Unraveling the Role of Innate Immune Pathways in Neurodegeneration
Bruce Lamb (Indiana University, USA)
Tuesday June 12
Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease: MODEL-AD
Harriet Williams (The Jackson Laboratory, USA)
The IU/JAX MODEL-AD Center and the Indiana Alzheimer’s Disease Center hosted a scientific symposium focusing on translational approaches to Alzheimer’s disease featuring speakers from the Stark Neurosciences Institute, The Jackson Lab, Sage Bionetworks and Eli Lilly as well as a poster session.
Thanks to sponsors: Alzheimer Association; Stark Neurosciences Research Institute; IU Alzheimer’s Disease Center; and Indiana Clinical and Translational Sciences Institute.
The Jackson Laboratory will present the 3rd annual Workshop on using mouse models to study human neurodegenerative disease in May. This course will focus on the use of the innovative tools and methods, specifically in the laboratory mouse, for answering questions of neuron and circuit function and disease mechanisms during neurodegeneration. The course will employ both didactic and hands-on instruction in both laboratory techniques and bioinformatics.
The Model Organism Development and Evaluation for Late-onset-Alzheimer’s Disease (MODEL-AD) project seeks a Center Manager for the Jackson Lab site in Bar Harbor, Maine. MODEL-AD aims to create the next generation of mouse models for AD and develop new therapeutic targets. The Center Manager is an integral team member in this multi-project, multi-institutional grant. The successful candidate will devote effort to managing the laboratory staff, overseeing mouse colony management, data production and analyses, and presenting research updates at internal and external meetings. Administrative responsibilities include serving as liaison between investigators at JAX, Indiana University (IU), and University of California-Irvine (UCI), communications between JAX MODEL-AD project leaders, and managing documentation for data use and lab and animal protocols. The successful candidate will be able to apply for grants to develop their own research interests that leverage the resources being developed within MODEL-AD.
More information and how to apply.
Some of the recent NIA Approved Concepts for funding (see https://www.nia.nih.gov/approved-concepts#collaborative ) encourage the use of mouse models created by the MODEL-AD program. All of the models generated will be listed on the “Resources” section of this website, and will be available from JAX. Please contact us at ModelAD@iupui.edu if you would like us to provide a letter of support.
We will be presenting our progress at the Alzheimer’s Association International Conference in London in July.
Monday July 17
Genetic Factors of Alzhemer’s Disease:
Cross Study Integrative Network Analysis Identification of AD Disease Etiology
Wednesday July 19
Basic and Translational Science: Development of New Models and Analysis Methods:
Model Organism Development and Evaluation for Late-Onset Alzheimer’s Disease: MODEL-AD
Wednesday July 19
Creating a Humanized Mouse Model of CR1 and CR2 to Better Model Alzheimer’s Disease Risk Factors
Wednesday July 19
Novel Candidate Loci for Late-Onset Alzheimer’s Disease from Bayesian Mixed Modeling of Whole-Genome and Whole-Exome Sequencing
The JAX MODEL-AD Center staff and friends participated in the The Longest Day to raise funds and awareness for the care, support and research efforts of the Alzheimer’s Association. We started the day with sunrise on the top of Cadillac Mountain, then hiked every peak in Acadia, paddled and swam in Long Pond, and ended the day with sunset at Pretty Marsh.
Together we raised more than $7,000 and spoke to many people throughout the day about the plight of Alzheimer’s patients and caregivers.
Thanks to all we participated and donated, and thanks to Adam Lacher of the Maine Chapter of the Alzheimer’s Association for joining us for lunch.
If you would like to donate, please go to our The Longest Day team page.
RNAseq data from the APP/PS1 model ( B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax ) is now available at the AMP-AD Knowledge Portal.
Transcriptomic data has been collected from left hemisphere of both WT and APP/PS1 mouse model. APP/PS1 double transgenic mice C57BL/6J.APPswePsen1de9 mice (herein referred to as B6.APBTg) were obtained from The Jackson Laboratory and maintained in 14/10-hour light/dark cycle. To generate experimental mice, B6.APBTg/+ mice were mated to C57BL/ 6 J (B6) mice to generate AD and wild-type (WT) cohorts. To minimize gene expression variation between mice, all mice in experimental cohorts were bred in the same mouse room, were aged together (to the extent possible) and only females were assessed. Mice from 2–12 months old were used in this study.