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MODEL-AD Presentations at SfN 2019

Monday, October 21, 2019

Session #354 – 4:15-4:30 PM – McCormick Place: Room S103
Title: Developing mouse models to study late-onset Alzheimer’s Disease
D. BAGLIETTO-VARGAS1,2, L. CAI1, M. NGUYEN1, K. HUYNH1, A.C. MARTINI1, L. TRUJILLO-ESTRADA1, C. SOTO3, I. MORENO-GONZALEZ3, S. VIVEK1,2, F.M. LAFERLA1,2 and MODEL-AD CONSORTIUM
1 Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.; 2 Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.; 3 The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA.

Tuesday, October 22, 2019

Poster Session #473.01/Poster Board #E20 – 8-9 AM – McCormick Place: Hall A
Title: Lifespan magnetic resonance imaging of novel mouse models of Alzheimer’s disease: Phenotyping and comparisons to healthy aging
A. JULLIENNE1, A. OBENAUS2,4, J. LEE5, E.J. BEHRINGER4, MODEL-AD CONSORTIUM3,6,7,8,9;
1Inst. for Memory Impairments and Neurolog. Disorders (UCI MIND), 2Dept. of Pediatrics, 3Univ. of California, Irvine, Irvine, CA; 4Basic Sci., 5Div. of Physiology, Sch. of Med., Loma Linda Univ., Loma Linda, CA; 6Indiana Univ., Indianapolis, IN; 7Jackson Lab., Bar Harbor, ME; 8Sage Bionetworks, Seattle, WA; 9Univ. of Pittsburg, Pittsburg, PA

Poster Session #473.02/Poster Board #E21 – 9-10 AM – McCormick Place: Hall A
Title: Development and characterization of novel mouse models of late onset Alzheimer’s disease
M. SASNER1, D. GARCEAU1, K. KOTREDES1, A. OBLAK2, C. INGRAHAM2, D. SONI2, H. WILLIAMS1, A. REAGAN1, A. UYAR1, R. PANDEY1, C. PREUSS1, B. LOGSDON4, P.R. TERRITO3, G. CARTER1, B.T. LAMB5, G.R. HOWELL1;
1The Jackson Lab., Bar Harbor, ME; 2STARK Neurosci. Res. Inst.; 3Radiology and Imaging Sci., Indiana Univ. Sch. of Med., Indianapolis, IN; 4Sage Bionetworks, Seattle, WA; 5Stark Neurosciences Res. Inst., Indianapolis, IN

Poster Session #473.03/Poster Board #E22 – 10-11 AM – McCormick Place: Hall A
Title: Characterization and Deep Phenotyping of the 5xfAD Mouse Model by MODEL-AD
S. FORNER for MODEL-AD

Poster Session #473.04/Poster Board #E23 – 11 AM–12 PM – McCormick Place: Hall A
Title: Uncoupling of cerebral blood flow and glucose metabolism in APOE4, TREM2, and APOE4.TREM2 mice
P. B. LIN1, S.A. PERSOHN2, A.A. BEDWELL2, L. JIANG2, K.M. ELDRIDGE2, R. SPEEDY2, K. KOTREDES4, R. PANDEY4, H. WILLIAMS4, A.L. OBLAK3, M. SASNER4, G.R. HOWELL4, G.W. CARTER4, B.T. LAMB1, P. R. TERRITO2
1STARK Neurosciences Res. Inst., Indianapolis, IN; 2Radiology and Imaging Sci., Indiana Univ. Sch. of Med., Indianapolis, IN; 3STARK Neurosci. Res. Inst., Indiana Univ. Sch. Of Med., Indianapolis, IN; 4The Jackson Lab., Bar Harbor, ME

Poster Session #473.05/Poster Board #E24 – 8-9 AM – McCormick Place: Hall A
Title: Multi-Phenotype Comparison of an Apoe4.Trem2*R47H Mouse Model and Human Late-Onset Alzheimer’s Disease
G.W. CARTER,1 R.S. PANDEY,1 K.P. KOTREDES,1 C. PREUSS,1 H. WILLIAMS,1 P. TERRITO,2 A. OBLAK,2 B. LAMB,2 S. RIZZO,1 M. SASNER,1 and G. HOWELL1 of the MODEL-AD CENTER1,2,3
1The Jackson Laboratory, Bar Harbor, Maine, USA 04609; 2Stark Neuroscience Research Institute, Indianapolis, Indiana, USA 46202; 3Sage Bionetworks, Seattle, Washington, USA 98121

Poster Session #473.06/Poster Board #E25 – 9-10 AM – McCormick Place: Hall A
Title: Modeling Trem2 variants in mice
A. L. OBLAK1, H. WILLIAMS3, K. KOTREDES3, M. SASNER3, S. J. SUKOFF RIZZO4, G. CARTER3, G.R. HOWELL3, C. PREUSS3, A. UYAR3, R.S. PANDY3, C. INGRAHAM1, D. SONI1, V. JADHAV1, A.P.-Y. TSAI1, P. R. TERRITO2, B. LOGSDON5, B. T. LAMB1
1Stark Neuroscience Research Institute, Indianapolis, Indiana, USA 46202; 2Radiology and Imaging Sci., Indiana Univ. Sch. of Med., Indianapolis, IN; 3The Jackson Laboratory, Bar Harbor, Maine, USA 04609; 4Univ. of Pittsburg, Pittsburg, PA; 5Sage Bionetworks, Seattle, Washington, USA 98121

Poster Session #473.07/Poster Board #E26 – 10-11 AM – McCormick Place: Hall A
Title: Comparative transcriptome analysis of MODEL-AD mouse models
G. BALDERRAMA-GUTIERREZ and A. MORTAZAVI on behalf of MODEL-AD

Poster Session #473.10/Poster Board #E29 – 10-11 AM – McCormick Place: Hall A
Title: Transcriptomic analysis of chronic levetiracetam treatment in aged 5XFAD mice: Relationship with pharmacokinetics and pharmacodynamics
S.J. SUKOFF RIZZO1, K.D. ONOS2, K. KEEZER3, L. HAYNES3, H. WILLIAMS3, S.K. QUINNEY4, A. MASTERS4, C. BIESDORF DE ALMEIDA4, A. A. BEDWELL4, J.A. MEYER5, C. INGRAHAM6, J. PETERS4, S.A. PERSOHN4, R. SPEEDY4, L. FIGUEIREDO4, K. ELDRIDGE4, M. SASNER3, A. OBLAK6, B.T. LAMB6, G. CARTER3, P.R. TERRITO5
1Univ. of Pittsburgh Sch. of Med., Pittsburgh, PA; 2Res., 3The Jackson Lab., Bar Harbor, ME; 5Radiology and Imaging Sci., 6Stark Neurosci. Res. Inst., 4Indiana Univ. Sch. of Med., Indianapolis, IN

0 comments on “MODEL-AD Presentations at AAIC 2019”

MODEL-AD Presentations at AAIC 2019

Sunday, July 14, 4:55-5:15 PM, Petree Hall C

#F1-07-03
Alzheimer’s Susceptibility Genes Implicate Microglial Activity
Julie Williams, PhD1,2; Rebecca Sims, PhD3; Philip Taylor, PhD2; Michael Sasner, PhD4; Harriet M Williams, MPhil4 and Gareth Howell, PhD3,4, (1)UK Dementia Research Institute, Cardiff University, Cardiff, United Kingdom, (2)UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, United Kingdom, (3)Cardiff University, Cardiff, United Kingdom, (4)The Jackson Laboratory, Bar Harbor, ME, USA

Monday, July 15, 9:30 AM – 4:15 PM, South Hall GH

Poster # P2-131
NOVEL APOE4.TREM2*R47H MOUSE MODEL: Building A Better Tool for Late-Onset Alzheimer’s Disease  2019 AAIC POSTER APOE4Trem2R47H
Kevin P Kotredes, PhD1; Christoph Preuss, PhD1; Ravi S Pandey, PhD2; Harriet M Williams, MPhil1; Paul R Territo, PhD3; Adrian L Oblak, PhD4; Bruce T. Lamb, PhD5; Stacey J Sukoff Rizzo, PhD1; Gregory W Carter, PhD1; Michael Sasner, PhD1; Gareth Howell, PhD1 and MODEL-AD Center, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)The Jackson Laboratory, Farmington, CT, USA, (3)Indiana University School of Medicine, Indianapolis, IN, USA, (4)Stark Neurosciences Research Institute, Indianapolis, IN, USA, (5)Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA

Poster #P2-133
Initial Characterization of Novel Mouse Models of Late Onset Alzheimer’s Disease Based on Human Genetic Associations  GWAS models poster 20190709 v2
Michael Sasner, PhD1; Adrian L Oblak, PhD2; Christoph Preuss, PhD1; Dylan Garceau1; Harriett Williams, MS1; Kevin P Kotredes, PhD1; Cynthia Ingraham3; Ravi S Pandey, PhD4; Asli Uyar, PhD1; Disha Soni, MA2; Benjamin A Logsdon, PhD5; Bruce T. Lamb, PhD3; Gregory W Carter, PhD1; Gareth Howell, PhD1 and the MODEL-AD Center, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)Stark Neurosciences Research Institute, Indianapolis, IN, USA, (3)Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA, (4)The Jackson Laboratory, Farmington, CT, USA, (5)Sage Bionetworks, Seattle, WA, USA

Poster #P2-206
Contribution of Focal Microvascular Disruption to Neuroinflammation and Tau Pathology in a Mouse Model of Impact Concussion and Chronic Traumatic Encephalopathy
Chad A. Tagge, PhD2; Juliet A. Moncaster, PhD1; Amanda Gaudreau-Balderrama, PhD2; Xiao-Lei Zhang, PhD3; Mark W. Wojnarowicz, PhD1; Katharine J. Babcock, MS1; Erich S. Franz, BS2; Sarah E. Chancellor, BS1; John H. Pietro, BS1; Joseph W. O’Brien, MS2; Xiuping Liu1; Noel F. Casey, PhD1; Nicola Lupoli1; Haiyan Lu, MD, PhD4; Olga Kokiko-Cochran, PhD4; Sudad Saman, PhD5; Asami Kondo, PhD6; Xiao Zhou7; Omid Miry3; Linnea R Vose3; Maria Ericsson, BS6; Kristen Onos, PhD8; Ronel Veksler, MD, PhD9; Vlad Senatorov, BS10; Katisha Gopaul3; Chirag Upreti, PhD3; Christopher Nowinski, PhD1; Robert Cantu, MD, PhD1; Victor E. Alvarez, MD11; Ning Hua, PhD1; Yorghos Tripodis, PhD12; Andrew Anderson, PhD13; Gareth Howell, PhD8; Daniela Kaufer, PhD10; Garth F. Hall, PhD5; Kun Ping Lu, MD, PhD14; Richard Ransohoff, MD15; Robin O. Cleveland, PhD16; Neil W Kowall, MD17; Bertrand R. Huber, MD, PhD11; Thor D. Stein, MD, PhD11; Bruce T. Lamb, PhD18; William C. Moss, PhD13; Alon Friedman, MD, PhD9; Patric K. Stanton, PhD3 and Ann C. McKee, MD1, (1)Boston University School of Medicine, Boston, MA, USA, (2)Boston University, Boston, MA, USA, (3)New York Medical College, Valhalla, NY, USA, (4)Cleveland Clinic, Cleveland, OH, USA, (5)University of Massachusetts Lowell, Lowell, MA, USA, (6)Harvard Medical School, Boston, MA, USA, (7)BIDMC, Boston, MA, USA, (8)The Jackson Laboratory, Bar Harbor, ME, USA, (9)Ben-Gurion University, Beersheba, Israel, (10)University of California, Berkeley, Berkeley, CA, USA, (11)VA Boston Healthcare System, Jamaica Plain, MA, USA, (12)Boston University School of Public Health, Boston, MA, USA, (13)Lawrence Livermore National Laboratory, Livermore, CA, USA, (14)BIDMC-Harvard Medical School, Boston, MA, USA, (15)Biogen, Cambridge, MA, USA, (16)University of Oxford, Oxford, United Kingdom, (17)Boston University Alzheimer’s Disease Center, Boston, MA, USA, (18)Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA

Poster #P2-105
A Novel Systems Biology Approach to Evaluate Mouse Models of Late Onset Alzheimer’s Disease: Ncounter Mouse AD Panel  AAIC POSTER NANOSTRING_2019_July3rd
Christoph Preuss, PhD1; Ravi S Pandey, PhD2; Alexander Fine, Msc1; Asli Uyar, PhD1; Benjamin A Logsdon, PhD3; Thanneer M Perumal, PhD3; Erin Piazza, PhD4; Elizabeth Rullo, PhD4; Jamie Kuhar, PhD4; Christina Bailey, PhD4; Lara M Mangravite, PhD3; Gareth Howell, PhD1; Michael Sasner, PhD1 and Gregory W Carter, PhD1, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)The Jackson Laboratory, Farmington, CT, USA, (3)Sage Bionetworks, Seattle, WA, USA, (4)NanoString Technologies, Inc., Seattle, WA, USA

Tuesday, July 16, 9:30 AM – 4:15 PM, South Hall GH

Poster #P3-111
Metabolic Assessment of Genetically Distinct Mouse Populations: Strain Matters in Mouse Models of Alzheimer’s Disease
Kristen Onos, PhD1; Kelly J. Keezer1; Jubilee Ajiboye1; Caroline Wise, MS1; Michael Sasner, PhD1; Gareth Howell, PhD1,2,3 and Heidi Kocalis, PhD1, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)Cardiff University, Cardiff, United Kingdom, (3)Tufts University, Boston, MA, USA

Poster #P3-142
Stratification of Alzheimers Patients Using Postmortem Brain Co-Expression Data Reveals Novel Genetic Modifiers Mediating Inflammatory Aging  AAIC POSTER AMPAD_MODULE_MAPPING_2019_July3rd
Christoph Preuss, PhD1; Benjamin A Logsdon, PhD2; Nikhil Milind, Bsc1; Annat Harber, PhD1; Asli Uyar, PhD1; Ravi S Pandey, PhD3; Thanneer M Perumal, PhD2; Lara M Mangravite, PhD2; Gareth Howell, PhD1; Michael Sasner, PhD1; Shubhabrata Mukherjee, PhD4; Paul K Crane, MD, MPH4; Gregory W Carter, PhD1 and MODEL-AD consortium, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)Sage Bionetworks, Seattle, WA, USA, (3)The Jackson Laboratory, Farmington, CT, USA, (4)University of Washington, Seattle, WA, USA

Poster #P3-069
Human Wild Type Aβ Knock-in Mice As a Basis to Study Sporadic Alzheimer’s Disease
David Baglietto-Vargas, Ph.D1; Stefania Forner, Ph.D1; Lena Cai, BS2; Alessandra Cadete Martini, Ph.D1; Laura Trujillo-Estrada, Ph.D1; Shan Jiang, PhD3; Enikö Kramár, PhD4; Cristina Nuñez-Diaz5; Mohammad Shahnawaz6; Dina P Matheos, PhD7; Xinyi Ma, PhD8; Celia Da Cunha1; Claudio Soto, PhD9; Antonia Gutierrez, PhD10; Ines Moreno-Gonzalez, PhD9; Grant R MacGregor, Ph.D2; Kim N Green, PhD2; Marcelo A Wood, Ph.D2; Ali Mortazavi, Ph.D2; Andrea Tenner, Ph.D.2 and Frank LaFerla, Ph.D1, (1)University of California – Irvine, Irvine, CA, USA, (2)University of California, Irvine, Irvine, CA, USA, (3)Department of Developmental and Cell Biology, University of California., Irvine, CA, USA, (4)Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA, (5)Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain, (6)The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street,, Houston, TX, USA, (7)Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA, (8)Department of Developmental and Cell Biology, University of California, Irvine, CA, USA, (9)The University of Texas Health Science Center at Houston, Houston, TX, USA, (10)Dept. Cell Biology, Faculty of Sciences, University of Malaga. CIBERNED. IBIMA., MALAGA, Spain

Wednesday, July 17, 9:30 AM – 4:15 PM, South Hall GH

Poster #P4-079
Critical Evaluation of the Pharmacokinetics of Verubecestat in Aged 5XFAD Mice  PTC AAIC POSTER 2019 – FINAL
Paul R Territo, PhD1; Sara K Quinney, PhD1; Carla Biesdorf, PhD2; Kristen Onos, PhD3; Leslie Haynes3; Kelly J. Keezer3; Jill A Meyer1; Jonathan Peters1; Scott C Persohn1; Amanda Bedwell2; Kierra Eldridge2; Rachael Speedy2; Michael Sasner, PhD3; Gareth Howell, PhD3; Harriet M Williams, MPhil3; Adrian L Oblak, PhD1; Bruce T. Lamb, PhD4 and Stacey J Sukoff Rizzo, PhD3, (1)Indiana University School of Medicine, Indianapolis, IN, USA, (2)Indiana University School of Medicine, INDIANAPOLIS, IN, USA, (3)The Jackson Laboratory, Bar Harbor, ME, USA, (4)Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA

Poster #P4-098
Transcriptomic Alterations Driven By the Trem2*R47H Allele Vary across Different Transgenic Mouse Models
Asli Uyar, PhD1; Adrian L Oblak, PhD2; Harriet M Williams, MPhil1; Ravi S Pandey, PhD3; Kevin P Kotredes, PhD1; Christoph Preuss, PhD1; Benjamin A Logsdon, PhD4; Stacey J Sukoff Rizzo, PhD1; Gareth Howell, PhD1; Bruce T. Lamb, PhD5; Michael Sasner, PhD1 and Gregory W Carter, PhD1, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)Indiana University School of Medicine, Indianapolis, IN, USA, (3)The Jackson Laboratory, Farmington, CT, USA, (4)Sage Bionetworks, Seattle, WA, USA, (5)Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA

Poster #P4-091
The Trem2*R47H Variant Alters Expression and Function in Mouse Models of Alzheimer’s Disease  Trem2R47HFINAL
Adrian L Oblak, PhD1,2; Harriet M Williams, MPhil3; Vaishnavi Jadhav1,2; Andy Tsai1,2; Disha Soni, MA1,2; Cynthia Ingraham4; Kevin P Kotredes, PhD3; Asli Uyar, PhD3; Ravi S Pandey, PhD5; Christoph Preuss, PhD3; Ben Logsdon, PhD6; Paul R Territo, PhD2; Stacey J Sukoff Rizzo, PhD3; Michael Sasner, PhD3; Gregory W Carter, PhD3; Gareth Howell, PhD3; Bruce T. Lamb, PhD4 and MODEL-AD Consortium, (1)Stark Neurosciences Research Institute, Indianapolis, IN, USA, (2)Indiana University School of Medicine, Indianapolis, IN, USA, (3)The Jackson Laboratory, Bar Harbor, ME, USA, (4)Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA, (5)The Jackson Laboratory, Farmington, CT, USA, (6)Sage Bionetworks, Seattle, WA, USA

Poster #P4-119
Molecular Estimation of Alzheimer’s Disease Progression
Sumit Mukherjee, PhD1; Christoph Preuss, PhD2; Anna K Greenwood, PhD1; Suman Jayadev, MD3; Gwenn A Garden, MD, PhD3; Gregory W Carter, PhD2; Lara M Mangravite, PhD1 and Benjamin A Logsdon, PhD1, (1)Sage Bionetworks, Seattle, WA, USA, (2)The Jackson Laboratory, Bar Harbor, ME, USA, (3)University of Washington, Seattle, WA, USA

Poster #P4-087
A Common Risk Variant in the MTHFR Gene Contributes to Cerebrovascular Dysfunction in Mixed Dementia
Alaina M Reagan, PhD1; Kevin P Kotredes, PhD1; Harriet M Williams, MPhil1; Rita O’Rourke1; Sarah O’Rourke1; Gregory W Carter, PhD1,2; Michael Sasner, PhD1; Gareth Howell, PhD1,2 and MODEL-AD Center, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)Tufts University, Boston, MA, USA

Wednesday, July 17, 4:15-4:30 PM, 502 AB

#04-09-01
Leveraging Mouse Genetic Diversity to Investigate the Role of Brain Myeloid Cells in Alzheimer’s Disease
Hongtian Yang, PhD1; Kristen Onos, PhD1; Asli Uyar, PhD1; Kwangbom Choi, PhD1; Kelly J. Keezer1; Rita O’Rourke1; Sarah O’Rourke1; Michael Sasner, PhD1; Gregory W Carter, PhD1,2 and Gareth Howell, PhD1,2, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)Tufts University, Boston, MA, USA

Thursday, July 18, 11:45 AM – 12:00 PM, 403 AB

#05-10-01
Enhanced Function of PLCg2 Variant P522R in Macrophages and Microglia Is Associated with Protection from Alzheimer’s Disease
Emily Maguire, PhD1; Georgina E Menzies, PhD1; Thomas Ernest James Philips, PhD1; Emma L Cope, PhD2; Magdalena Czubala, PhD3; Neil Evans1; Gareth Howell, PhD4,5; Harriet M Williams, MPhil4,5; Michael Sasner, PhD5; Emyr Lloyd-Evans, PhD2; Rebecca Sims, PhD6; Julie Williams, PhD1; Nicholas D Allen, PhD1,2 and Philip Taylor, PhD1,3, (1)UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, United Kingdom, (2)School of Biosciences, Cardiff University, Cardiff, United Kingdom, (3)Systems Immunity Research Institute, Cardiff University, Cardiff, United Kingdom, (4)Cardiff University, Cardiff, United Kingdom, (5)The Jackson Laboratory, Bar Harbor, ME, USA, (6)Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

0 comments on “A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease”

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

Preuss C, Pandey R, Piazza E, Fine A, Uyar A, Perumal T, Garceau D, Kotredes KP, Williams H, Mangravite LM, Lamb BT, Oblak AL, Howell GR, Sasner M, Logsdon BA, Carter GW. A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease. bioRxiv 2019 doi: https://doi.org/10.1101/682856

0 comments on “nanoString Webinar Thursday, 3/14/19”

nanoString Webinar Thursday, 3/14/19

A gene expression-based screening platform for mouse models of late-onset Alzheimer’s disease
When: Thursday, March 14, 9:00 a.m. PT
Speaker: Greg Carter, PhD, Associate Professor, The Jackson Laboratory
Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide, but to-date animal models of Alzheimer’s have focused on rare familial mutations. This is due to a lack of frank neuropathology from models based on common disease genes. Recent multi-cohort studies of postmortem human brain transcriptomes have identified a set of 30 gene co-expression modules associated with LOAD, providing a molecular catalog of relevant endophenotypes. Join this webinar to learn how to rapidly and reproducibly assess disease relevance of potential LOAD mouse models using gene expression analysis.
0 comments on “Identifying and ranking potential driver genes of Alzheimer’s Disease using multi-view evidence aggregation”

Identifying and ranking potential driver genes of Alzheimer’s Disease using multi-view evidence aggregation

In Mukherjee et al, we provide a generalizable framework for integration of diverse systems biology outputs to rank and identify new transcriptomic and genetic drivers of Alzheimer’s disease. This provides evidence that integration of multiple systems biology resources can provide insights into new Alzheimer’s disease loci, which can help researchers prioritize future experimental studies focusing on specific genes and pathways that are driving disease etiology.

0 comments on “MODEL-AD Presentations at ADPD Annual Conference March 26-31, 2019, Lisbon, Portugal”

MODEL-AD Presentations at ADPD Annual Conference March 26-31, 2019, Lisbon, Portugal

Wednesday, March 27th, 08:00-18:00, Exhibition Session Code A7.a

DEEP PHENOTYPING OF THE 5XFAD MOUSE MODEL USING THE MODEL-AD PIPELINE   ADPD 5xFAD poster AO
A. Oblak, H. Williams, G. Carter, S. Sukoff-Rizzo, M. Sasner, P. Territo, G. Howell, B. Lamb.
Indiana University School of Medicine, Stark Neurosciences Research Institute, Indianapolis, USA.
The Jackson Laboratory, MODEL-AD, Bar Harbor, USA.
Indiana University School of Medicine, Radiology & Imaging Sciences, Indianapolis, USA.

MODELS OF LATE ONSET ALZHEIMER’S DISEASE: THE MODEL-AD CONSORTIUM  ADPD MODEL-AD overview poster AO
A. Oblak, G. Carter, G. Howell, S. Sukoff-Rizzo, M. Sasner, P. Territo, H. Williams, B. Lamb, A. Mortazavi, M. Wood, S. Forner, G. MacGregor, A. Tenner, K. Green, F. LaFerla.
Indiana University School of Medicine, Stark Neurosciences Research institute, Indianapolis, USA.
The Jackson Laboratory, MODEL-AD, Bar Harbor, USA.
University of California Irvine, MODEL-AD, Irvine, USA.

TREM2R47H MICE SHOW A TWO-FOLD REDUCTION IN EXPRESSION AND PROTEIN LEVELS OF TREM2  ADPD Trem2R47H poster AO
A. Oblak, R. Pandey, G. Carter, H. Williams, G. Howell, M. Sasner, B. Lamb.
Indiana University School of Medicine, Stark Neurosciences Research Institute, Indianapolis, USA.
The Jackson Laboratory, MODEL-AD, Bar Harbor, USA.

EVALUATION OF CHRONIC TREATMENT WITH LEVETIRACETAM ON PHARMACOKINETCS AND PHARMACODYNAMICS IN 5XFAD MICE
S. Rizzo, S. Quinney, K. Onos, K. Keezer, L. Haynes, D. Jones, A. Masters, C. Biesdorf De Almeida, J. Meyer, J. Peters, S. Persohn, A. Bedwell, D. McKinzie, M. Sasner, G. Howell, H. Williams, A. Oblak, B. Lamb, P. Territo.
The Jackson Laboratory, Center for Biometric Analysis, Bar Harbor, USA.
Indiana University, School of Medicine, Indianapolis, USA.
The Jackson Laboratory, Institute for Mammalian Genomics, Bar Harbor, USA.

NOVEL MOUSE MODELS OF LATE-ONSET ALZHEIMER’S DISEASE EXPRESSING RISK VARIANTS AT GWAS LOCI    ADPD GWAS models poster MS
M. Sasner, A. Oblak, H. Williams, C. Preuss, G. Carter, G. Howell, B. Lamb.
The Jackson Laboratory, MODEL-AD, Bar Harbor, USA.
Indiana University, Stark Neurosciences Research Institute, Indianapolis, USA.

CHARACTERIZATION OF A NOVEL MOUSE MODEL EXPRESSING APOE4 AND TREM2*R47h FOR FURTHERING THE UNDERSTANDING OF LATE ONSET ALZHEIMER’S DISEASE    ADPD APOE4-Trem2 poster MS
M. Sasner, A. Oblak, H. Williams, S. Rizzo, P. Territo, G. Howell, B. Lamb.
The Jackson Laboratory, MODEL-AD, Bar Harbor, USA.
Indiana University, Stark Neurosciences Research Institute, Indianapolis, USA.

CHARACTERIZATION OF MOUSE MODELS BASED ON CANDIDATE GENES ASSOCIATED WITH LATE ONSET ALZHEIMER’S DISEASE   ADPD transcriptomics poster RP
R. Pandey
The Jackson Laboratory, MODEL-AD, Bar Harbor, USA

Thursday, March 28th, 17:20 – 19:20, Auditorium VIII, Session code:S28

DEVELOPING THE NEXT GENERATION OF ANIMAL MODELS OF LATE-ONSET ALZHEIMER’S DISEASE
F. Laferla
University of California Irvine, School of Biological Sciences, Irvine, USA.

HUMAN WILD-TYPE ABETA KNOCK-IN MICE AS A BASIS TO STUDY SPORADIC ALZHEIMER’S DISEASE
D. Baglietto-Vargas, L. Cai, A. Martini, L. Trujillo-Estrada, S. Forner, S. Jiang, E. Kramár, C. Nuñez-Diaz, M. Shahnawaz, M. Dina, X. Ma, C. Da Cunha, R. Ager, C. Soto, A. Gutierrez, I. Moreno-Gonzalez, G. MacGregor, K. Green, M. Wood, A. Mortazavi, A. Tenner, F. LaFerla.
University of California- Irvine, Institute for Memory Impairments and Neurological Disorders, Irvine, USA.
University of California- Irvine, Department of Developmental and Cell Biology, Irvine, USA.
University of Malaga, Department of Cell Biology- Genetic and Physiology- Faculty of Sciences- Biomedical Research Institute of Malaga IBIMA- Networking Research Center on Neurodegenerative Diseases CIBERNED, Malaga, Spain.
University of Texas Health Science Center at Houston, The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders- Department of Neurology- McGovern Medical School, Houston, USA.

Friday, March 29th, 17:15 – 19:15, Auditorium VI+VII

NEXT-GENERATION MOUSE MODELS OF ALZHEIMER’S DISEASE
G. Carter
The Jackson Laboratory, MODEL-AD, Bar Harbor, USA

0 comments on “Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach”

Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach

Logsdon et al have used data from the AMP-AD consortium to identify consensus gene clusters that are differentially expressed in Alzheimer’s disease.

The MODEL-AD consortium has worked with nanoString  to develop a transcriptomics panel to assay these modules in mouse models.

We expect that this will be a rapid, cost-effective and highly reproducible approach to assess clinical relevance of novel models, to monitor disease progression, and to assay potential therapeutics.  The transcriptomics panel is now available from nanoString.

 

0 comments on “MODEL-AD Presentations at the 2018 Society for Neuroscience Meeting”

MODEL-AD Presentations at the 2018 Society for Neuroscience Meeting

Monday, November 5, 1:30pm – 4pm
Session 345: Global Efforts to Build More Predictive Animal Models of Neurodegenerative Disease
Chair: Bruce T. Lamb, PhD, Indiana University School of Medicine
Co-Chair: Rudolph E. Tanzi, PhD, Massachusetts General Hospital, Harvard Medical School
Location: SDCC 6B 2:45-3:20PM
345.04 Bruce Lamb: Novel insights into Alzheimer’s disease through the MODEL-AD consortium

Nanosymposium 267: Alzheimer’s Disease: Neuroinflammation and Immune Actions
Location: SDCC 24
10:15-10:30 267.10 Kristen Onos: Genetic diversity is a significant driver of amyloid-induced neuroinflammation and neurodegeneration in APP/PS1 mice

Tuesday November 6
Poster Session 466: Alzheimer’s Disease and Other Dementias: Genetic Analysis and Omics Approaches
Systems biology-based method to identify and prioritize Alzheimer’s disease candidate driver genes
S. Mukherjee, T. M. Perumal, K. Daily, S. Sieberts, L. Omberg, C. Preuss, G. Carter, L. Mangravite, B. Logsdon
Board F23, #462.20 presented 11:00-12:00am

Poster Session 467: Alzheimer’s Disease and Other Dementias: Therapeutic Strategies: Preclinical Animal Models II
Novel models of late-onset Alzheimer’s disease
Mike Sasner for the MODEL-AD Center   Sasner SfN 2018 GWAS poster final
Board G8, #467.01 presented 8:00-9:00am

hAb-KI: A knock-in mouse model for sporadic Alzheimer’s disease
Stefania Forner for the MODEL-AD Center
Board G9, #467.02, presented 9:00-10:00am

MODEL-AD: Late-onset Alzheimer’s disease models
Adrian Oblak for the MODEL-AD Center   Oblak OverviewFINAL
Board G10, #467.03 presented 10:00-11:00am

Preclinical screening strategy of the MODEL-AD consortium: Evaluation of the pharmacokinetics and pharmacodynamics of treatment with Levetiracetam
Stacey Rizzo for the MODEL-AD Center   Rizzo et al SfN PTC MODELAD Poster – 20181029 vPRT_sjsr_FINAL
Board G11, #467.04 presented 11:00am-noon

Translational genetic and genomic analyses of new mouse models of Alzheimer’s disease
Greg Carter for the MODEL-AD Center   Carter_SFN_2018
Board G12, #467.05 presented 8:00-9:00am

MODEL-AD: Standardized characterization of familial Alzheimer’s disease models (5xFAD, 3Tg-AD, APP/PS1, and hTau)
Gareth Howell for the MODEL-AD Center   Howell FAD SfN MODEL-AD poster
Board G13, #467.06 presented 9:00-10:00am

Wednesday, November 7, 1:00 PM – 3:15 PM
Nanosymposium 713: Alzheimer’s Disease and Other Dementias: Abeta: Pathologic Mechanisms
Location: SDCC 33

1:45-2:00 713.04 David Baglietto-Vargas hAb-KI mice: A novel tool for investigating risk factors in sporadic Alzheimer’s cases

 

 

 

 

0 comments on “The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.”

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.

A recent publication from the lab of Christian Haass has shown altered splicing of mouse Trem2 that is dependent upon the presence of the R47H mutation and leads to a cryptic splice site in exon 2 and a deletion of 119 nucleotides.

The MODEL-AD project has similar data demonstrating the cryptic splice site.  We are currently using Western blots and whole-brain transcriptomic analysis to assay mutant protein levels.  For now, we argue that the conclusion that “functional data derived from Trem2*R47H knock-in mice cannot be translated to humans” put forward in this paper may be premature because full-length transcripts are generated in Trem2*R47H homozygotes, albeit at reduced levels.

In parallel, we are considering alternative strategies to create Trem2 alleles to model late-onset AD.

AlzForum story

Article in PubMed