0 comments on “MODEL-AD presentations at ICMN”

MODEL-AD presentations at ICMN

Monday June 11

SHORT TALKS I

15:51-16:03

GWAS-based mouse models exhibit distinct transcriptomic signatures of late-onset Alzheimer’s disease

Greg Carter (The Jackson Laboratory, USA)

 

Tuesday June 12

SESSION 6: INNATE IMMUNITY AND NEURODEGENERATION

13:10-13:35

Unraveling the Role of Innate Immune Pathways in Neurodegeneration

Bruce Lamb (Indiana University, USA)

 

Tuesday June 12

Poster P2-K14

Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease: MODEL-AD

Harriet Williams (The Jackson Laboratory, USA)

0 comments on “Indiana U. Alzheimer’s symposium”

Indiana U. Alzheimer’s symposium

The IU/JAX MODEL-AD Center and the Indiana Alzheimer’s Disease Center hosted a scientific symposium focusing on translational approaches to Alzheimer’s disease featuring speakers from the Stark Neurosciences Institute, The Jackson Lab, Sage Bionetworks and Eli Lilly as well as a poster session.

Thanks to sponsors: Alzheimer Association; Stark Neurosciences Research Institute; IU Alzheimer’s Disease Center; and Indiana Clinical and Translational Sciences Institute.

 

IU symposium group shot

0 comments on “Workshop on the use of mouse models to study neurodegenerative disease”

Workshop on the use of mouse models to study neurodegenerative disease

The Jackson Laboratory will present the 3rd annual Workshop on using mouse models to study human neurodegenerative disease in May.  This course will focus on the use of the innovative tools and methods, specifically in the laboratory mouse, for answering questions of neuron and circuit function and disease mechanisms during neurodegeneration.  The course will employ both didactic and hands-on instruction in both laboratory techniques and bioinformatics.

Workshop details

0 comments on “Center Manager position available”

Center Manager position available

The Model Organism Development and Evaluation for Late-onset-Alzheimer’s Disease (MODEL-AD) project seeks a Center Manager for the Jackson Lab site in Bar Harbor, Maine.  MODEL-AD aims to create the next generation of mouse models for AD and develop new therapeutic targets. The Center Manager is an integral team member in this multi-project, multi-institutional grant.  The successful candidate will devote effort to managing the laboratory staff, overseeing mouse colony management, data production and analyses, and presenting research updates at internal and external meetings.  Administrative responsibilities include serving as liaison between investigators at JAX, Indiana University (IU), and University of California-Irvine (UCI), communications between JAX MODEL-AD project leaders, and managing documentation for data use and lab and animal protocols. The successful candidate will be able to apply for grants to develop their own research interests that leverage the resources being developed within MODEL-AD.

 

More information and how to apply.

0 comments on “Letters of support for NIA funding proposals”

Letters of support for NIA funding proposals

Some of the recent NIA Approved Concepts for funding (see https://www.nia.nih.gov/approved-concepts#collaborative ) encourage the use of mouse models created by the MODEL-AD program.  All of the models generated will be listed on the “Resources” section of this website, and will be available from JAX.  Please contact us at ModelAD@iupui.edu if you would like us to provide a letter of support.

0 comments on “MODEL-AD Presentations at Neuroscience 2017”

MODEL-AD Presentations at Neuroscience 2017

MONDAY, NOV. 13, 2017

Session 386 Alzheimer’s Disease: Genetics and Functional Genomic (1:00 – 5:00 PM)

 

Presentation 386.01 / V26 / 1:00-2:00

Model-ad: Genetic models of late-onset Alzheimer’s disease

 

Presentation 386.05 / W4 / 1:00-2:00

MODEL-AD: The disease modeling project

 

Presentation 386.02 / W1 / 2:00-3:00

Preclinical drug screening in new generation Alzheimer’s disease mouse models: The MODEL-AD Consortium Strategy

 

Presentation 386.03 / W2 / 3:00-4:00

Novel candidate loci for Alzheimer’s disease from whole-genome and whole-exome sequencing

 

Presentation 386.04 / W3 / 4:00-5:00

Model-ad: Bioinformatics and data management core

 

0 comments on “MODEL-AD presentations at AAIC”

MODEL-AD presentations at AAIC

We will be presenting our progress at the Alzheimer’s Association International Conference in London in July.

Monday July 17

Genetic Factors of Alzhemer’s Disease:

Cross Study Integrative Network Analysis Identification of AD Disease Etiology 

P2-101

 

Wednesday July 19

Basic and Translational Science: Development of New Models and Analysis Methods:

Model Organism Development and Evaluation for Late-Onset Alzheimer’s Disease: MODEL-AD

P4-060

 

Wednesday July 19

Developing Topics:

Creating a Humanized Mouse Model of CR1 and CR2 to Better Model Alzheimer’s Disease Risk Factors

P4-398

 

Wednesday July 19

Developing Topics:

Novel Candidate Loci for Late-Onset Alzheimer’s Disease from Bayesian Mixed Modeling of Whole-Genome and Whole-Exome Sequencing

P4-414

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The Longest Day

The JAX MODEL-AD Center staff and friends participated in the The Longest Day to raise funds and awareness for the care, support and research efforts of the Alzheimer’s Association.  We started the day with sunrise on the top of Cadillac Mountain, then hiked every peak in Acadia, paddled and swam in Long Pond, and ended the day with sunset at Pretty Marsh.

Together we raised more than $7,000 and spoke to many people throughout the day about the plight of Alzheimer’s patients and caregivers.

Thanks to all we participated and donated, and thanks to Adam Lacher of the Maine Chapter of the Alzheimer’s Association for joining us for lunch.

If you would like to donate, please go to our The Longest Day team page.

 

0 comments on “APP/PS1 RNAseq data release”

APP/PS1 RNAseq data release

RNAseq data from the APP/PS1 model ( B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax ) is now available at the AMP-AD Knowledge Portal.

Transcriptomic data has been collected from left hemisphere of both WT and APP/PS1 mouse model. APP/PS1 double transgenic mice C57BL/6J.APPswePsen1de9 mice (herein referred to as B6.APBTg) were obtained from The Jackson Laboratory and maintained in 14/10-hour light/dark cycle. To generate experimental mice, B6.APBTg/+ mice were mated to C57BL/ 6 J (B6) mice to generate AD and wild-type (WT) cohorts. To minimize gene expression variation between mice, all mice in experimental cohorts were bred in the same mouse room, were aged together (to the extent possible) and only females were assessed. Mice from 2–12 months old were used in this study.