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New APOE4/Trem2 model

A newly created mouse model of Alzheimer’s disease will be available soon.  This expresses the two strongest genetic risk factors for late-onset AD: the human APOE4 allele and a knock-in of the R47H allele into the mouse Trem2 locus.

This has not been fully characterized yet, we are aging cohorts to be phenotyped as of April 2017.

This model is now available to register interest; doing so will allow you to place your order as soon as possible, and will enable JAX to scale the distribution colony to meet the demand. This can be done from the strain data sheet.

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MODEL-AD presentations at AD/PD conference

The MODEL-AD Center will be presenting posters at the AD/PD conference in Vienna:

Tuesday, March 28:

Pre-Conference Symposium:  COMMON FEATURES OF NEURODEGENERATIVE DISEASES: EXPLORING THE BRAIN-EYE CONNECTION AND BEYOND

11:40-11:55  THE COMPLEMENT CASCADE IN ALZHEIMER’S DISEASE AND GLAUCOMA

Wednesday, March 29:

Poster #104:  NOVEL RODENT MODELS OF LATE-ONSET ALZHEIMER’S DISEASE

Thursday March 30:

Poster #181:  NOVEL CANDIDATE LOCI FOR LATE-ONSET ALZHEIMER’S DISEASE IDENTIFIED WITH BAYESIAN MIXED MODELING

Poster #45:  TREM2 DEFICIENCY IMPACTS MYELOID CELL FUNCTION AND AMYLOID PATHOLOGY IN A DISEASE-STAGE DEPENDENT MANNER IN MOUSE MODELS OF ALZHEIMER’S DISEASE

Friday March 31:

Symposium 33 – Microbiome and Nutrition

16:15-16:30  DIET-INDUCED NEUROINFLAMMATION AND VASCULAR DYSFUNCTION CAUSE WHITE MATTER DAMAGE IN THE AGING BRAIN