Common
name
Genetic background Strain Nomenclature Availability  Source
familial AD-related models
5XFAD B6J B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax live Bob Vassar
APP/PS1 B6J B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax live Dave Borchelt
3XTg-AD mixed B6; 129 B6;129-Psen1tm1MpmTg(APPSwe,tauP301L)1Lfa/Mmjax live Frank LaFerla
3XTg-AD B6J B6.Cg-Psen1tm1MpmTg(APPSwe,tauP301L)1Lfa/Mmjax Fall ’18 MODEL-AD
hTau B6J B6.Cg-Mapttm1(EGFP)KltTg(MAPT)8cPdav/J live Peter Davies
Late-onset AD-related models
APOE4/Trem2*R47H B6J B6(SJL)-Apoetm1.1(APOE*4)AdiujTrem2em1Adiuj/J live MODEL-AD
APOE4 KI B6J B6(SJL)-Apoetm1.1(APOE*4)Adiuj/J live MODEL-AD
APOE3 KI B6J B6(SJL)-Apoeem2(APOE*)Adiuj/J live MODEL-AD
hAbeta-loxP-KI mixed B6J; B6N B6(SJL)-Apptm1.1Aduci/J Fall ’18 MODEL-AD
hAbeta-loxP-KI B6NJ B6N(Cg)-Apptm1.1Aduci/J Fall ’18 MODEL-AD
Trem2*R47H B6J C57BL/6J-Trem2em1Adiuj/J live MODEL-AD
Trem2*Y38C B6J C57BL/6J-Trem2em3Adiuj/J live MODEL-AD
Trem2 KO B6J C57BL/6J-Trem2em2Adiuj/J live MODEL-AD
floxed Trem2 B6J B6(C3)-Trem2tm1c(EUCOMM)Wtsi/AdiujJ live KOMP/MODEL-AD